FIRST TRIMESTER HUMAN UMBILICAL CORD PERIVASCULAR CELLS (HUCPVC) MODULATE THE KYNURENINE PATHWAY AND GLUTAMATE NEUROTRANSMISSION IN AN LPS-INDUCED MOUSE MODEL OF NEUROINFLAMMATION

First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation

Abstract Background The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression.The therapeutic potential of mesenchymal stromal cells (MSC), owing to their well documented phagocytosis-driven mechanism of immunomodulation and neuroprotection, has been tested in

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A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2

GSX2 is a homeobox transcription factor (TF) controlling the specification of the ventral lateral ganglionic eminence and swish supreme glide track white its major derivative, the corpus striatum.Medium spiny neurons (MSNs) represent the largest cell component of the striatum and they are primarily affected in Huntington disease (HD).Here, we used

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Deep learning to distinguish Best vitelliform macular dystrophy (BVMD) from adult-onset vitelliform macular degeneration (AVMD)

Abstract Initial stages of Best vitelliform macular dystrophy (BVMD) and adult vitelliform macular dystrophy (AVMD) harbor similar blue autofluorescence (BAF) and optical coherence tomography (OCT) features.Nevertheless, BVMD is characterized by a worse final stage visual acuity (VA) and an earlier onset of critical VA loss.Currently, differential

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